Anti-Gout

Indomethacin (lndocin)

• 25-50mg tid (25, 50, supp 50, susp 25mg/5ml)
• (Indocin SR)-75mg PO qd/bid
• strong NSAID

 

Allopurinol (zyloprim, Purinol)

• 200-300mg PO qd/bid [100, 300]
• inhibits xanthine oxidase(a major enzyme in uric acid synthesis)

 

Colchicine

• po 1mg initially
• 0.5mg q1-2h until nausea/vomiting or diarrhea occur to a maximum dose of 7-8mg,
• IV 2mg initially, then 0.5mg q6h to a maximum dose of 4mg
• acts by interfering with WBCs ability to phagocytize urate crystals thus reducing inflammation
• very effective for acute attacks, but side effects often out weigh the advantages
• can be used as a diagnostic tool for acute gout, if symptoms are relieved, it was gout

 

Probenecid (Benemid)

• 250mg PO bid x7 days, then 500 bid
• inhibits the reabsorption of uric acid in the proximal tubules

 

Sulfinpyrazone (Anyurane)

• 100-200mg PO bid [100, 200]